Warning regarding accidental injection of Gudair sheep vaccine

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SPONSORED: General practitioners have been reminded of the potential medical implications of unintentional exposure to the Gudair vaccine.

Even a small amount of vaccine fluid can cause severe swelling and a persistent granulomatous inflammatory reaction.


General practitioners working in sheep production areas in the Australian region are encouraged to be on high alert for adverse events in patients exposed to Gudair – a vaccine given to sheep, primarily when tagging lambs .

Gudair, a vaccine containing inactivates mycobacterium paratuberculosis combined with a mineral oil adjuvant, is used to control ovine Johne’s disease (OJD), a debilitating, incurable disease.

Zoetis is undertaking an extensive education program for all rural stores and veterinary clinics that stock Gudair, to promote the safe use of Gudair which involves proper handling and vaccination of vaccines using a specialized safety vaccinator , with a safe working environment for competent and experienced staff.

Nevertheless, accidental injection in humans can still occur and even a small amount of vaccine fluid can cause severe swelling and a persistent granulomatous inflammatory reaction.

For example, if injected into a finger joint or tendon sheath, the product can follow the tendon and as a result swelling and inflammation can compromise the blood supply and lead to necrosis and, in rare cases, an amputation.

To avoid serious side effects, people are advised to seek medical attention promptly.

Every case is different and the right medical advice is up to the attending physician.

“Doctors have discovered that treating a case of accidental self-injection in humans may require rapid surgery to remove the vaccine,” reads a letter to regional doctors from Zoetis, the Australian distributor. by Gudair.

Zoetis is aware that the following treatment strategies are frequently recommended for needlestick injuries.

Needlestick injuries without a known vaccine injection

  • Doctors recommended that the wound can bleed freely and that the wound or injection site not be squeezed or interfered in any way. Doctors recommended that the wound should then be washed thoroughly with lukewarm water and kept clean and dry.
  • Doctors have also considered that after appropriate immediate local cleansing, corticosteroids may decrease the severity of any local reaction.
  • Doctors frequently determined the patient’s tetanus vaccination status and gave him a booster or a primary vaccination, as appropriate.
  • Usually, if there is no pain or swelling 24 hours after exposure, doctors continued to monitor for at least a month and treat clinical symptoms accordingly.

If the pain and swelling are present after 24 hours, the doctors considered it to be an accidental injection and treated the injury as described below.

Needlestick injuries with vaccine injection

  • Doctors have observed that the sharp pain and inflammation are usually still evident 24 hours after the suspected injection.
  • In cases of self-injection, doctors felt that prompt surgery was needed, and in these cases, doctors cut the wound to remove the vaccine, especially if the pulp of the finger was involved. or tendon.
    • In the case of a lesion that progressed to necrosis or granulomatous ulceration, doctors performed surgical debridement to remove residual vaccine material.
  • Doctors said meticulous technique was needed to stop accidental spread of the product during surgery

Given the nature of this mineral oil-based vaccine, Zoetis recommends that any healthcare professional
speak with a surgeon who has experience with the treatment.

Likewise, if a person is exposed to Silirum, a vaccine that contains inactivated mycobacteria and mineral oil adjuvant, GPs are recommended to follow the same guidelines.

If there is a case of accidental self-injection, general practitioners are advised to contact Zoetis at 1 800 814 883 for more information.

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Gudair mycobacterium paratuberculosis vaccine


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